When evaluating the combination of mETE, tumor size, and aggressive PTC histology, the presence of mETE with a >2 cm tumor was significantly associated with a worse outcome (OR 5.27, p = 0.014). Statistical analysis suggested that mETE (odds ratio 1.16, p = 0.65), tumor size >2 cm (OR 1.45, p = 0.34), aggressive PTC histology (OR 0.55, p = 0.15), and age at diagnosis (OR 0.90, p = 0.32) were not significant risk factors for a worse initial therapy response. Results: At 1-year follow-up, 1831 patients (81.8%) had an excellent response, 296 (13.2%) had an indeterminate response, 55 (2.5%) had a biochemical incomplete response, and 55 (2.5%) had a structural incomplete response. For each case, we considered initial surgery, histological variant of PTC, tumor diameter, recurrence risk class according to the American Thyroid Association (ATA) risk stratification system, use of radioiodine therapy, and initial therapy response, as suggested by ATA guidelines. Methods: We reviewed all records in the Italian Thyroid Cancer Observatory database and selected 2237 consecutive patients with PTC who satisfied the inclusion criteria (PTC with no lymph node metastases and at least 1 year of follow-up). The aims of this study were to assess the clinical impact of mETE as a predictor of worse initial treatment response in PTC patients and to verify the impact of radioiodine therapy after surgery in patients with mETE. 28 Division of Endocrine Surgery, Fondazione Policlinico Gemelli, Catholic University, Rome, Italy.īackground: The role of minimal extrathyroidal extension (mETE) as a risk factor for persistent papillary thyroid carcinoma (PTC) is still debated.27 Struttura Complessa Chirurgia Oncologica della Tiroide, Istituto Nazionale Tumori-IRCCS-Fondazione G.
26 Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.25 Endocrinology Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.24 Endocrinology Unit, Tinchi Hospital, Matera, Italy.23 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio," University of Florence, Florence, Italy.22 Pathology Unit, University Hospital Campus Bio-Medico, Rome, Italy.21 Pathology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.20 Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.19 Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.18 Department of Endocrinology and Diabetes, Azienda Ospedaliero-Universitaria Sant'Andrea, Sapienza University of Rome, Roma, Italy.17 Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Verona, Verona, Italy.16 Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.15 Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy.14 Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
12 SCDU Endocrinology, Andrology and Metabolism, Humanitas Gradenigo Hospital, Turin, Italy.11 Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.10 Department of Medicine and Surgery, University of Parma, Parma, Italy.9 UO Endocrinologia, Diabetologia e Malattie del metabolismo, AO Ordine Mauriziano Torino, Torino, Italy.8 Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.7 Department of Medicine and Surgery, University of Perugia, Perugia, Italy.6 Division of Oncological Endocrinology, Città della Salute e della Scienza Hospital, Turin, Italy.5 Department of Medical Sciences, Unit of Endocrinology, University of Ferrara, Ferrara, Italy.4 Chair and Nuclear Medicine Unit, University and Spedali Civili Hospital, Brescia, Italy.3 Department of Statistical Sciences, Sapienza University of Rome, Rome, Italy.2 Department of Translational and Precision Medicine, and Sapienza University of Rome, Rome, Italy.1 Department of Medical, Surgical, and Neurological Sciences, University of Siena, Siena, Italy.
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